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當前位置:首頁 > 抗原抗體、ELISA、WB > 一抗 > Polyclonal Antibodies > TRPM5 Antibody

TRPM5 Antibody

貨號 貨期 規格 / 價格 詢價
APR13816G  In Stock 50 μl / ¥6950

TRPM5 Antibody

品牌

Leading Biology

貨號

APR13816G

產品分類

Polyclonal Antibodies

研究領域

產品概述

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality TRPM5 antibody.

分子量

130844 Da

宿主

Rabbit

種屬反應性

Human, Mouse, Rat

靶點

Peptide GSGKKRGKFVKVPS(C), corresponding to amino acid residues 32-45 of mouse TRPM5 (Accession Q9JJH7).????Intracellular, N-terminus.

基因ID

UniProt ID

總結

The mammalian melastatin-related transient receptor potential (TRPM) is a subfamily of the TRP family. The family was named afterthe first discovered member, melastatin (TRPM1) whose gene was identified in metastatic and benign melanomas1-3.The TRPM family consists of eight members designated as TRPM1-8 that can be further divided into four pairs: TRPM1 and TRPM3; TRPM2 and TRPM8; TRPM4 and TRPM5; and TRPM6 and TRPM71,2.The TRPM proteins share structural homology with other members of the TRP superfamily channels; six putative transmembrane domains, and cytoplasmic N- and C-termini. However, due to theirlong N- and C-termini they are also named the long TRP channel family1-3.TRPM4 and TRPM5 are the only TRP channels that are permeable to monovalent cations but not to Ca2+.TRPM4 is expressed as at least two alternative spliced isoforms, TRPM4a and TRPM4b which consist of shorter and longer N-terminal regions, respectively. TRPM4a displays little activity, TRPM4b and TRPM5 appear to be directly activated by an increase in intracellular Ca2+ concentration4,5.TRPM5 is primarily expressed in taste buds and also in stomach, small intestine, uterus and testes2.Regulation of TRPM5 by G-protein-coupled receptors and PLC-mediated IP3 production has been substantiated by the colocalization of TRPM5, of a taste-cell-specific PLC isoform and of receptors for sweet, bitter and amino acid (umami) tastes in taste tissue. It has furthermore been shown that desensitization of TRPM5 following receptor stimulation can be reversed by phosphatidylinositol (4,5)-bisphosphate (PIP2), the substrate of PLC2.Abgent is pleased to offer a highly specific antibody directed against an intracellular epitope of the mouse TRPM5. The Anti-TRPM5 antibody (#AG1343) can be used in western blot and immunohistochemical applications. It has been designed to recognize TRPM5 from mouse, rat and human samples.

形式

Affinity purified antibody, Liquid

儲存條件

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

應用

WB

稀釋方法

WB~~1:200-1:2000 IHC~~1:100

別名

Transient receptor potential cation channel subfamily M member 5, Long transient receptor potential channel 5, LTrpC-5, LTrpC5, MLSN1- and TRP-related gene 1 protein, Trpm5 {ECO:0000312|MGI:MGI:1861718}

圖像

Western blot analysis of rat lung membrane (lanes 1 and 2), rat testes (lanes 3 and 4), mouse ms1 cells (lanes 5 and 7) and human LNCaP cell (lanes 6 and 8) lysates: 1, 3, 5, 6. Anti-TRPM5 antibody ( APR13816G), (1:200). 2, 4, 7, 8. Anti-TRPM5 antibody, preincubated with the control peptide antigen.

Expression of TRPM5 in rat tongue Immunohistochemical staining of rat tongue paraffin embedded sections using Anti-TRPM5 antibody ( APR13816G), (1:100). TRPM5 is expressed in discrete groups of cells deep in the sulcus of the papillae. Hematoxilin is used as the counterstain.

Expression of TRPM5 in rat testes Immunohistochemical staining of rat epididymis paraffin embedded sections using Anti-TRPM5 antibody ( APR13816G), (1:100). TRPM5 is expressed in principal cells within the epididymal epithelium (arrows). Hematoxilin is used as the counterstain.

說明書

數量

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