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VEGF (Vascular Endothelial Growth Factor) Antibody - Without BSA and Azide

貨號 貨期 規格 / 價格 詢價
APG01369G  In Stock 100 μg / ¥4950

VEGF (Vascular Endothelial Growth Factor) Antibody - Without BSA and Azide

品牌

Leading Biology

貨號

APG01369G

產品分類

Monoclonal Antibodies

研究領域

產品概述

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality VEGF (Vascular Endothelial Growth Factor) antibody - Without BSA and Azide.

分子量

19-22kDa (reducing) and 38kDa-44kDa (non-reducing)

細胞定位

Antigen Cellular Localization: Secreted Note=VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a signicant proportion remains cell-associated, most is freely secreted VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin

宿主

Mouse

種屬反應性

Human, Mouse, Rat, Rabbit, Dog

克隆號

VEGF/1063

亞型

Mouse / IgG1, kappa

通用名

VEGF

基因ID

UniProt ID

功能

Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth.

總結

This MAb recognizes proteins of 19-22kDa (reducing) and 38kDa-44kDa (non-reducing), identified as various isoforms of Vascular Endothelial Growth Factor or Vascular Permeability Factor (VEGF/VPF). It is highly specific to VEGF, which is a homodimeric, disulfide-linked glycoprotein with a close homology to platelet derived growth factor (PDGF). There are multiple isoforms of VEGF containing 206-, 189-, 165-, and 121-amino acid residues. The smaller two isoforms, VEGF165 and VEGF121, are secreted proteins and act as diffusible agents, whereas the larger two remain cell associated. VEGF/VPF plays an important role in angiogenesis, which promotes tumor progression and metastasis.

形式

Liquid

儲存條件

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

應用

IHC, IF

別名

Vascular endothelial growth factor A, VEGF-A, Vascular permeability factor, VPF, VEGFA, VEGF

圖像

Formalin-fixed, paraffin-embedded human Ovarian Carcinoma stained with VEGF Monoclonal Antibody (VEGF/1063).

Formalin-fixed, paraffin-embedded human Tonsil stained with VEGF Monoclonal Antibody (VEGF/1063).

說明書

數量

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