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Bombesin Receptor 2 (extracellular) Antibody

貨號 貨期 規格 / 價格 詢價
AMM05633G  In Stock 50 μl / ¥6950

Bombesin Receptor 2 (extracellular) Antibody

品牌

Leading Biology

貨號

AMM05633G

產品分類

Polyclonal Antibodies

研究領域

產品概述

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Bombesin Receptor 2 (extracellular) antibody.

分子量

43199 Da

宿主

Rabbit

種屬反應性

Human, Mouse, Rat

靶點

Peptide (C)RSYHYSEVDTSMLH, corresponding to amino??acid??residues 287-300 of human BB2 (Accession P30550). 3rd extracellular loop.

基因ID

UniProt ID

總結

Bombesin receptor 2 (BB2) is a member of a family of receptors that binds the 14 amino acid peptide, bombesin. Bombesin was first isolated from frog skin and it was later established that mammals express endogenous bombesin-like peptides such as gastrin-releasing peptide (GRP; a 27 amino acid homologue) and neuromedin B (NMB; a 10 amino acid homologue).BB2 is the preferred receptor for GRP and hence it is also referred to as GRP receptor or GRP-R.1 BB1 is the preferred receptor for NMB and therefore it is also known as NMB-R. A third member (called BB3) of the bombesin receptor family has been recognized but the endogenous mammalian ligand for this receptor remains to be identified.All three bombesin receptors are members of the seven-transmembrane domain, G protein-coupled receptor (GPCR) superfamily. BB2 is coupled to a Gq/11 protein that activates phospholipase C (PLC) and leads to production of inositol 1,4,5-trisphosphate (InsP3), intracellular Ca2+ mobilization, and cell growth.2GRP (through its binding to BB2) plays an essential role in the release of hormones in the intestinal tract, the regulation of smooth muscle contraction, and the secretion of pancreatic enzymes.2 In the brain, BB2 has been implicated in regulating feeding behavior, thermoregulation, and memory formation.3Finally, BB2 is overexpressed in several human tumors including breast, prostate, and lung, where it acts as a growth factor receptor inducing tumor growth. BB2 is considered a potential target for the development of both diagnostics and anti-cancer therapies.4Abgent is pleased to offer a highly specificantibody directed against an epitope located in the 3rd extracellular loop of the human BB2 receptor. Anti-Bombesin Receptor2 (extracellular)antibody(#AG1369) can be used in western blot analysis, as well asimmunocytochemical and immunohistochemical applications, and will recognize BB2 from human, rat, mouse, and dog samples.

形式

Affinity purified antibody, Liquid

儲存條件

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

應用

WB, LCI

稀釋方法

WB~~1:200-1:2000 IHC~~1:50 ICC~~1:100

別名

Gastrin-releasing peptide receptor, GRP-R, GRP-preferring bombesin receptor, GRPR

圖像

Western blot analysis of rat (lanes 1 and 3) and mouse (lanes 2 and 4) brain lysates: 1, 2. Anti-Bombesin Receptor 2 (extracellular) antibody ( AMM05633G), (1:500). 3, 4. Anti-Bombesin Receptor 2 (extracellular) antibody, preincubated with the control peptide antigen.

Western blot analysis of human DU-145 (lanes 1 and 3) and PC-3 (lanes 2 and 4) prostate carcinoma cell lines: 1, 2. Anti-Bombesin Receptor 2 (extracellular) antibody ( AMM05633G), (1:200). 3, 4. Anti-Bombesin Receptor 2 (extracellular) antibody, preincubated with the control peptide antigen.

Expression of Bombesin Receptor 2 in human colon Immunohistochemical staining of paraffin-embedded human colon using Anti-Bombesin Receptor 2 (extracellular) antibody ( AMM05633G), (1:50). (A and B) Human colon showing malignant growth. Staining is specific for epithelium-derived malignant cells. (C and D) Normal colon, staining is specific for absorptive epithelial cells in the crypts of Lieberkuhn. Histofine (pink) is used for the color reaction. Hematoxilin is used as the counterstain.

說明書

數量

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